Tag Archives: polyphenols in Moringa

First research of high polyphenols in Moringa Oleifera leaves

The first research of high polyphenols in Moringa Oleifera leaves.


This research is the first comprehensive identification of conserved and novel miRNAs in Moringa Oleifera leaf, seed, and callus (stressed and non-stressed).

The first research of high polyphenols in Moringa Oleifera leaves.

This dataset represents an important supplement to the existing Moringa Oleifera miRNA database and shall be useful in understanding the possible role for enhancing biosynthesis of pharmacologically important phytochemicals by plant miRNAs during biotic and abiotic stresses.

In the past decade, Moringa Oleifera has gained growing attention for its nutraceutical and pharmacological functions as well as potential benefits for human health; several studies have demonstrated the great number of bioactive compounds contained in leaves, seeds, pods, and flowers1,2,4. A large number of these bioactive compounds (such as secondary metabolites) might explain the pharmacological properties of this “miracle tree”. Recent studies have confirmed the high content of polyphenols (such as flavonoids and phenolic acids) in Moringa Oleifera leaves65. These secondary metabolites are synthesized in the plant for its specialized need, in particular, ecological conditions; unlike primary metabolites, secondary metabolites are directly involved in the defense mechanism against environmental injuries. In humans, Moringa Oleifera polyphenols (such as flavonoids) are involved in protection against chronic diseases associated with oxidative stress, including cardiovascular disease and cancer4.

MicroRNAs, a class of small, non-coding RNAs, play important roles in plant growth, development and stress response by negatively regulating gene expression. Moringa Oleifera Lam. plant has many medical and nutritional uses; however, little attention has been dedicated to its potential for the bio production of active compounds. In this study, 431 conserved and 392 novel microRNA families were identified and 9 novel small RNA libraries constructed from leaf, and cold stress treated callus, using high-throughput sequencing technology. Based on the Moringa Oleifera genome, the microRNA repertoire of the seed was re-evaluated. qRT-PCR analysis confirmed the expression pattern of 11 conserved microRNAs in all groups. MicroRNA159 was found to be the most abundant conserved microRNA in leaf and callus, while microRNA393 was most abundantly expressed in the seed. The majority of predicted microRNA target genes were transcriptional factors involved in plant reproduction, growth/development, and abiotic/biotic stress response. In conclusion, this is the first comprehensive analysis of microRNAs in Moringa Oleifera leaf and callus which represents an important addition to the existing Moringa Oleifera seed microRNA database and allows for possible exploitation of plant microRNAs induced with abiotic stress, as a tool for bio-enrichment with pharmacologically important phytochemicals.
Read here the full analyses….

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The first research of high polyphenols in Moringa Oleifera leaves.